Article
Deep Learning and Pathomics Analyses Reveal Cell Nuclei as Important Features for Mutation Prediction of BRAF-Mutated Melanomas.
The Journal of investigative dermatology - 1 Jun 2022
Kim Randie H, Nomikou Sofia, Coudray Nicolas, Jour George, Dawood Zarmeena, Hong Runyu, Esteva Eduardo, Sakellaropoulos Theodore, Donnelly Douglas, Moran Una, Hatzimemos Aristides, Weber Jeffrey S, Razavian Narges, Aifantis Iannis, Fenyo David, Snuderl Matija, Shapiro Richard, Berman Russell S, Osman Iman, Tsirigos Aristotelis
Abstract excerpt
Image-based analysis as a method for mutation detection can be advantageous in settings when tumor tissue is limited or unavailable for direct testing. In this study, we utilize two distinct and complementary machine-learning methods of analyzing whole-slide images for predicting mutated BRAF. In the first method, whole-slide images of melanomas from 256 patients were used to train a deep convolutional neural...
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