Rapid Screening Using Pathomorphologic Interpretation to Detect BRAFV600E Mutation and Microsatellite Instability in Colorectal Cancer.

doi:10.1158/1078-0432.CCR-21-4391

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Article

Rapid Screening Using Pathomorphologic Interpretation to Detect BRAFV600E Mutation and Microsatellite Instability in Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 13 Jun 2022

Fujii Satoshi, Kotani Daisuke, Hattori Masahiro, Nishihara Masato, Shikanai Toshihide, Hashimoto Junji, Hama Yuki, Nishino Takuya, Suzuki Mizuto, Yoshidumi Ayatoshi, Ueno Makoto, Komatsu Yoshito, Masuishi Toshiki, Hara Hiroki, Esaki Taito, Nakamura Yoshiaki, Bando Hideaki, Yamada Tomoyuki, Yoshino Takayuki

Abstract excerpt

PURPOSE: Rapid decision-making is essential in precision medicine for initiating molecular targeted therapy for patients with cancer. This study aimed to extract pathomorphologic features that enable the accurate prediction of genetic abnormalities in cancer from hematoxylin and eosin images using deep learning (DL). EXPERIMENTAL DESIGN: A total of 1,657 images (one representative image per patient) of thin...

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PMID: 35363302
DOI: 10.1158/1078-0432.CCR-21-4391

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