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Article

Genes identified in rodent studies of alcohol intake are enriched for heritability of human substance use.

Alcoholism, clinical and experimental research - 1 Dec 2021

Huggett Spencer B, Johnson Emma C, Hatoum Alexander S, Lai Dongbing, Srijeyanthan Jenani, Bubier Jason A, Chesler Elissa J, Agrawal Arpana, Palmer Abraham A, Edenberg Howard J, Palmer Rohan H C

Abstract excerpt

BACKGROUND: Rodent paradigms and human genome-wide association studies (GWAS) on drug use have the potential to provide biological insight into the pathophysiology of addiction. METHODS: Using GeneWeaver, we created rodent alcohol and nicotine gene-sets derived from 19 gene expression studies on alcohol and nicotine outcomes. We partitioned the SNP heritability of these gene-sets using four large human GWAS: (1)...

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Source

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Identifiers

PMID: 34751961
DOI: 10.1111/acer.14738
PMCID: PMC9714312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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