Article
Phenotype-tissue expression and exploration (PTEE) resource facilitates the choice of tissue for RNA-seq-based clinical genetics studies.
BMC genomics - 7 Nov 2021
Velluva Akhil, Radtke Maximillian, Horn Susanne, Popp Bernt, Platzer Konrad, Gjermeni Erind, Lin Chen-Ching, Lemke Johannes R, Garten Antje, Schöneberg Torsten, Blüher Matthias, Abou Jamra Rami, Le Duc Diana
Abstract excerpt
BACKGROUND: RNA-seq emerges as a valuable method for clinical genetics. The transcriptome is "dynamic" and tissue-specific, but typically the probed tissues to analyze (TA) are different from the tissue of interest (TI) based on pathophysiology. RESULTS: We developed Phenotype-Tissue Expression and Exploration (PTEE), a tool to facilitate the decision about the most suitable TA for RNA-seq. We integrated...
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