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Article

Association analysis of KIR/HLA genotype with liver cirrhosis, hepatocellular carcinoma, and NUC freedom in chronic hepatitis B patients.

Scientific reports - 2 Nov 2021

Joshita Satoru, Ota Masao, Kobayashi Hiroyuki, Wakabayashi Shun-Ichi, Yamashita Yuki, Sugiura Ayumi, Yamazaki Tomoo, Tanaka Eiji, Umemura Takeji

Abstract excerpt

Natural killer cells are modulated through the binding of killer cell immunoglobulin-like receptors (KIRs) with human leukocyte antigen (HLA) class I ligands. This study investigated the association of KIR/HLA pairs with progression to liver cirrhosis, hepatocellular carcinoma (HCC) development, and nucleot(s)ide (NUC) treatment freedom in hepatitis B virus (HBV) infection. KIR, HLA-Bw, and HLA-C were genotyped...

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Share to Carcinoma, Hepatocellular
Share to Hepatitis B, Chronic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis B virus

Share to HLA-B Antigens

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Share to Receptors, KIR

Share to Receptors, KIR3DL1

Source

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Identifiers

PMID: 34728722
DOI: 10.1038/s41598-021-01014-x
PMCID: PMC8563771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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