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Association analysis of KIR/HLA genotype with liver cirrhosis, hepatocellular carcinoma, and NUC freedom in chronic hepatitis B patients.

Scientific reports - 2 Nov 2021

Joshita Satoru, Ota Masao, Kobayashi Hiroyuki, Wakabayashi Shun-Ichi, Yamashita Yuki, Sugiura Ayumi, Yamazaki Tomoo, Tanaka Eiji, Umemura Takeji

Abstract excerpt

Natural killer cells are modulated through the binding of killer cell immunoglobulin-like receptors (KIRs) with human leukocyte antigen (HLA) class I ligands. This study investigated the association of KIR/HLA pairs with progression to liver cirrhosis, hepatocellular carcinoma (HCC) development, and nucleot(s)ide (NUC) treatment freedom in hepatitis B virus (HBV) infection. KIR, HLA-Bw, and HLA-C were genotyped...

Topics

Aged
Carcinoma, Hepatocellular
Female
Follow-Up Studies
Genotype
HLA-B Antigens
Hepatitis B virus
Hepatitis B, Chronic
Humans
Liver Cirrhosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Neoplasms

Male

Middle Aged

Nucleosides

Prognosis

Receptors, KIR

Receptors, KIR3DL1

Retrospective Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 34728722
DOI: 10.1038/s41598-021-01014-x
PMCID: PMC8563771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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