KIR and HLA loci are associated with hepatocellular carcinoma development in patients with hepatitis B virus infection: a case-control study.

doi:10.1371/journal.pone.0025682

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Article

KIR and HLA loci are associated with hepatocellular carcinoma development in patients with hepatitis B virus infection: a case-control study.

PloS one - 1 Jan 2011

Pan Ning, Jiang Wei, Sun Hang, Miao Fengqin, Qiu Jie, Jin Hui, Xu Jinhuan, Shi Qian, Xie Wei, Zhang Jianqiong

Abstract excerpt

BACKGROUND: Natural killer (NK) cells activation has been reported to contribute to inflammation and liver injury during hepatitis B virus (HBV) infection both in transgenic mice and in patients. However, the role of NK cells in the process of HBV-associated hepatocellular carcinoma (HCC) development has not been addressed. Killer cell immunoglobulin-like receptors (KIRs) are involved in regulating NK cell...

Topics

Adult
Carcinoma, Hepatocellular
Case-Control Studies
Disease Progression
Female
Gene Dosage
Genetic Loci
Genetic Predisposition to Disease
HLA Antigens
Hepatitis B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Killer Cells, Natural

Liver Neoplasms

Male

Middle Aged

Receptors, KIR

Source

Open in PubMed Open full text

Identifiers

PMID: 21998681
DOI: 10.1371/journal.pone.0025682
PMCID: PMC3187788

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