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Article

Low-frequency Coding Variants Associated With Body Mass Index Affect the Success of Bariatric Surgery.

The Journal of clinical endocrinology and metabolism - 17 Feb 2022

Antoine Darlène, Guéant-Rodriguez Rosa-Maria, Chèvre Jean-Claude, Hergalant Sébastien, Sharma Tanmay, Li Zhen, Rouyer Pierre, Chery Céline, Halvick Sarah, Bui Catherine, Oussalah Abderrahim, Ziegler Olivier, Quilliot Didier, Brunaud Laurent, Guéant Jean-Louis, Meyre David

Abstract excerpt

CONTEXT: A recent study identified 14 low-frequency coding variants associated with body mass index (BMI) in 718 734 individuals predominantly of European ancestry. OBJECTIVE: We investigated the association of 2 genetic scores (GS) with i) the risk of severe/morbid obesity, ii) BMI variation before weight-loss intervention, iii) BMI change in response to an 18-month lifestyle/behavioral intervention program, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34718599
DOI: 10.1210/clinem/dgab774

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