Article
Understanding alpha-globin gene regulation: Aiming to improve the management of thalassemia.
Annals of the New York Academy of Sciences - 1 Jan 2005
Higgs D R, Garrick D, Anguita E, De Gobbi M, Hughes J, Muers M, Vernimmen D, Lower K, Law M, Argentaro A, Deville M A, Gibbons R
Abstract excerpt
Over the past 50 years, many advances in our understanding of the general principles controlling gene expression during hematopoiesis have come from studying the synthesis of hemoglobin. Discovering how the alpha- and beta-globin genes are normally regulated and documenting the effects of inherited mutations that cause thalassemia have played a major role in establishing our current understanding of how genes are...
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