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Article

Interleukin-6 mediates delirium-like phenotypes in a murine model of urinary tract infection.

Journal of neuroinflammation - 28 Oct 2021

Rashid Mohammad Harun, Sparrow Nicklaus A, Anwar Faizan, Guidry Gena, Covarrubias Ambart E, Pang Haoming, Bogguri Chandrakumar, Karumanchi S Ananth, Lahiri Shouri

Abstract excerpt

BACKGROUND: Urinary tract infection (UTI) is frequently implicated as a precipitant of delirium, which refers to an acute confusional state that is associated with high mortality, increased length of stay, and long-term cognitive decline. The pathogenesis of delirium is thought to involve cytokine-mediated neuronal dysfunction of the frontal cortex and hippocampus. We hypothesized that systemic IL-6 inhibition...

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Identifiers

PMID: 34711238
DOI: 10.1186/s12974-021-02304-x
PMCID: PMC8554965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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