Article
17β-estradiol ameliorates delirium-like phenotypes in a murine model of urinary tract infection.
Scientific reports - 15 Nov 2022
Guidry Gena, Sparrow Nicklaus A, Marshall Hyyat S, De Souza Santos Roberta, Bharath Suman P, Gezalian Michael M, Pisarska Margareta D, Vit Jean-Philippe, Kelly Scott A, Karumanchi S Ananth, Lahiri Shouri
Abstract excerpt
Urinary tract infections (UTIs) are common and frequently precipitate delirium-like states. Advanced age coincident with the postmenopausal period is a risk factor for delirium following UTIs. We previously demonstrated a pathological role for interleukin-6 (IL-6) in mediating delirium-like phenotypes in a murine model of UTI. Estrogen has been implicated in reducing peripheral IL-6 expression, but it is unknown...
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