Article
Systemic interleukin-6 inhibition ameliorates acute neuropsychiatric phenotypes in a murine model of acute lung injury.
Critical care (London, England) - 13 Sept 2022
Anwar Faizan, Sparrow Nicklaus A, Rashid Mohammad Harun, Guidry Gena, Gezalian Michael M, Ley Eric J, Koronyo-Hamaoui Maya, Danovitch Itai, Ely E Wesley, Karumanchi S Ananth, Lahiri Shouri
Abstract excerpt
Acute neuropsychiatric impairments occur in over 70% of patients with acute lung injury. Mechanical ventilation is a well-known precipitant of acute lung injury and is strongly associated with the development of acute delirium and anxiety phenotypes. In prior studies, we demonstrated that IL-6 mediates neuropathological changes in the frontal cortex and hippocampus of animals with mechanical ventilation-induced...
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