Article
Comparison of solid tissue sequencing and liquid biopsy accuracy in identification of clinically relevant gene mutations and rearrangements in lung adenocarcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2021
Lin Lawrence Hsu, Allison Douglas H R, Feng Yang, Jour George, Park Kyung, Zhou Fang, Moreira Andre L, Shen Guomiao, Feng Xiaojun, Sabari Joshua, Velcheti Vamsidhar, Snuderl Matija, Cotzia Paolo
Abstract excerpt
Screening for therapeutic targets is standard of care in the management of advanced non-small cell lung cancer. However, most molecular assays utilize tumor tissue, which may not always be available. "Liquid biopsies" are plasma-based next generation sequencing (NGS) assays that use circulating tumor DNA to identify relevant targets. To compare the sensitivity, specificity, and accuracy of a plasma-based NGS...
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