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Mechanisms and Consequences of Newcastle Disease Virus W Protein Subcellular Localization in the Nucleus or Mitochondria

14 Jan 2021

Abstract excerpt

In contrast, very little is known about the function of NDV W protein, and this limited information is based on studies of the Nipah virus W protein. Here, we investigated the localization mechanism of NDV W protein and its subcellular distribution in mitochondria. We found that W protein localization differences impact IFN-β production, consequently affecting NDV virulence, replication, and pathogenicity. This...

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PMID: 33441338
DOI: 10.1128/jvi.02087-20

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