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Liposomal SDF-1 Alpha Delivery in Nanocomposite Hydrogels Promotes Macrophage Phenotype Changes and Skin Tissue Regeneration.

ACS biomaterials science & engineering - 8 Nov 2021

Yu Justine R, Varrey Pranav, Liang Barry J, Huang Huang-Chiao, Fisher John P

Abstract excerpt

Skin regeneration in chronic wounds is often delayed due to persistent inflammation induced by underlying conditions such as diabetes. This effect is mediated, in part, by macrophages present in the wound, which can be stimulated to adopt either pro- or anti-inflammatory phenotypes depending on the status of the local microenvironment. In this work, the prohealing chemokine stromal cell-derived factor-1 alpha...

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PMID: 34699182
DOI: 10.1021/acsbiomaterials.1c01140

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