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Article

Childhood-onset mild diabetes caused by a homozygous novel variant in the glucokinase gene.

Hormones (Athens, Greece) - 1 Mar 2022

Filibeli Berna Eroğlu, Çatli Gönül, Ayranci İlkay, Manyas Hayrullah, Kirbiyik Özgür, Dündar Bumin

Abstract excerpt

PURPOSE: Heterozygous loss-of-function mutations in the glucokinase (GCK) gene cause MODY 2, which is characterized by asymptomatic fasting hyperglycemia and does not require insulin treatment. Conversely, homozygous loss-of-function mutations in the same gene give rise to permanent neonatal diabetes mellitus (DM) that appears in the first 6-9 months of life and necessitates lifelong insulin treatment. We aimed...

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Source

Identifiers

PMID: 34697762
DOI: 10.1007/s42000-021-00330-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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