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Article

Why all MODY variants are dominantly inherited: a hypothesis.

Trends in genetics : TIG - 1 Apr 2022

Li Meihang, Rivière Jean-Baptiste, Polychronakos Constantin

Abstract excerpt

Maturity-onset diabetes in the young (MODY) comprises monogenic phenotypes of young-onset, insulinopenic diabetes. All its forms are dominantly inherited. Why? Are the pancreatic β cells only harmed by heterozygous variants? We propose that recessive MODYs do exist but have escaped detection due to lack of family history suggestive of monogenic inheritance.

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PMID: 34696899
DOI: 10.1016/j.tig.2021.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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