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Human papillomavirus and molecular considerations for cancer risk

3 Nov 2008

Abstract excerpt

Human papillomaviruses (HPVs) are a major cause of cancer globally, including cervical cancer. The HPV 'early' proteins, E6 and E7, are the chief oncoproteins involved in cancer progression. These oncoproteins are more highly expressed in high-grade dysplasias and invasive cancer coincident with reduced viral DNA replication and reduced production of infective progeny virions. The E6 and E7 oncoproteins interact...

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PMID: 18980282
DOI: 10.1002/cncr.23750

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