Ciliopathy organoid models: a comprehensive review.

Abstract excerpt

Cilia are membrane-bound organelles found on the surface of most mammalian cell types and play numerous roles in human physiology and development, including osmo- and mechanosensation, as well as signal transduction. Ciliopathies are a large group of, usually rare, genetic disorders resulting from abnormal ciliary structure or ciliary dysfunction that have a high collective prevalence. Autosomal dominant or...

Topics

• Humans
• Organoids
• Animals
• Ciliopathies
• Cilia
• Disease Models, Animal
• Induced Pluripotent Stem Cells
• Phenotype