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Article

Could Cytochrome P450 2D6, 3A4 and 3A5 Polymorphisms Explain the Variability in Clinical Response to Clomiphene Citrate of Anovulatory PCOS Women?

Frontiers in endocrinology - 1 Jan 2021

Robin Camille, Hennart Benjamin, Broly Franck, Gruchala Philippine, Robin Geoffroy, Catteau-Jonard Sophie

Abstract excerpt

Introduction: Cytochrome P450 2D6, 3A4 and 3A5 are involved in the metabolism of many drugs. These enzymes have a genetic polymorphism responsible for different metabolic phenotypes. They play a role in the metabolism of clomiphene citrate (CC), which is used to induce ovulation. Response to CC treatment is variable, and no predictive factors have thus far been identified. Objective: To study a possible link...

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Identifiers

PMID: 34690927
DOI: 10.3389/fendo.2021.718917
PMCID: PMC8535872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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