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Article

A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.

Nature communications - 22 Oct 2021

MacAlpine Jessie, Daniel-Ivad Martin, Liu Zhongle, Yano Junko, Revie Nicole M, Todd Robert T, Stogios Peter J, Sanchez Hiram, O'Meara Teresa R, Tompkins Thomas A, Savchenko Alexei, Selmecki Anna, Veri Amanda O, Andes David R, Fidel Paul L, Robbins Nicole, Nodwell Justin, Whitesell Luke, Cowen Leah E

Abstract excerpt

The fungus Candida albicans is an opportunistic pathogen that can exploit imbalances in microbiome composition to invade its human host, causing pathologies ranging from vaginal candidiasis to fungal sepsis. Bacteria of the genus Lactobacillus are colonizers of human mucosa and can produce compounds with bioactivity against C. albicans. Here, we show that some Lactobacillus species produce a small molecule under...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34686660
DOI: 10.1038/s41467-021-26390-w
PMCID: PMC8536679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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