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Article

Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis

28 Jun 2012

Abstract excerpt

Because of their genetically determined capacity to respond to pro-inflammatory stimuli, keratinocytes have a crucial role in the pathogenesis of psoriasis. Upon IFN-γ and TNF-α exposure, psoriatic keratinocytes express exaggerated levels of inflammatory mediators, and show aberrant hyperproliferation and terminal differentiation. The thickening of psoriasic skin also results from a peculiar resistance of...

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PMID: 22739986
DOI: 10.1038/cddis.2012.69

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