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Article

Cross-sectional and longitudinal interaction effects of physical activity and APOE-ε4 on white matter integrity in older adults: The MAPT study.

Maturitas - 1 Oct 2021

Raffin Jérémy, Rolland Yves, He Lingxiao, Perus Lisa, Mangin Jean-François, Gabelle Audrey, Virecoulon Giudici Kelly, Vellas Bruno, de Souto Barreto Philipe

Abstract excerpt

BACKGROUND: Physical activity (PA) has been shown to modulate the detrimental effect of carrying the apolipoprotein-E epsilon 4 (APOE-ɛ4) allele on brain structure. However, the current literature mainly provides cross-sectional data, and longitudinal studies investigating the interaction between genotype and PA on white matter (WM) integrity are lacking. OBJECTIVES: We investigated both the cross-sectional and...

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PMID: 34674803
DOI: 10.1016/j.maturitas.2021.06.010

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