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Article

Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt/β-catenin-Cyp2e1 Signaling.

International journal of biological sciences - 1 Jan 2021

Chen Li-Jie, Lin Xiu-Xian, Guo Jing, Xu Ying, Zhang Song-Xia, Chen Dan, Zhao Qing, Xiao Jian, Lian Guang-Hui, Peng Shi-Fang, Guo Dong, Yang Hong, Shu Yan, Zhou Hong-Hao, Zhang Wei, Chen Yao

Abstract excerpt

Background: Nonalcoholic fatty liver disease (NAFLD) is a serious threat to human health worldwide, with a high genetic susceptibility. Rs2302685, a functional germline variant of LRP6, has been recently found to associate with NAFLD risk. This study was aimed to clarify the underlying mechanism associated with rs2302685 risk and its impact on pharmacotherapy in treatment of NAFLD. Methods: Venous blood samples...

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Identifiers

PMID: 34671210
DOI: 10.7150/ijbs.63732
PMCID: PMC8495406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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