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Article

Genome-wide association study of colorectal polyps identified highly overlapping polygenic architecture with colorectal cancer.

Journal of human genetics - 1 Mar 2022

Hikino Keiko, Koido Masaru, Otomo Nao, Tomizuka Kohei, Ikegawa Shiro, Matsuda Koichi, Momozawa Yukihide, Mushiroda Taisei, Terao Chikashi

Abstract excerpt

No genome-wide association studies (GWAS) were reported for colorectal polyps and the overlap in polygenic backgrounds conferring risk of colorectal cancer and polyps remains unclear. We performed GWAS on subjects with colorectal polyps using the BioBank Japan data with 4447 cases and 157,226 controls. We evaluated genetic correlations between colorectal polyps and cancer, and effects on colorectal polyps of...

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PMID: 34671089
DOI: 10.1038/s10038-021-00980-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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