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Article

AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis.

The New England journal of medicine - 21 Oct 2021

Morelle Johann, Marechal Céline, Yu Zanzhe, Debaix Huguette, Corre Tanguy, Lambie Mark, Verduijn Marion, Dekker Friedo, Bovy Philippe, Evenepoel Pieter, Bammens Bert, Selgas Rafael, Bajo Maria A, Coester Annemieke M, Sow Amadou, Hautem Nicolas, Struijk Dirk G, Krediet Raymond T, Balligand Jean-Luc, Goffin Eric, Crott Ralph, Ripoche Pierre, Davies Simon, Devuyst Olivier

Abstract excerpt

BACKGROUND: Variability in ultrafiltration influences prescriptions and outcomes in patients with kidney failure who are treated with peritoneal dialysis. Variants in AQP1, the gene that encodes the archetypal water channel aquaporin-1, may contribute to that variability. METHODS: We gathered clinical and genetic data from 1851 patients treated with peritoneal dialysis in seven cohorts to determine whether AQP1...

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Identifiers

PMID: 34670044
DOI: 10.1056/NEJMoa2034279

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