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Article

The Synergistic Inhibitory Effect of Combining MK-2206 and AZD 6244 in MARIMO Cells Harboring a Calreticulin Gene Mutation.

Chemotherapy - 1 Jan 2021

Wang Chunqing, Hu Xueting, Wan Yan, Wang Shujin, Qi Kunming, Li Yanjie, Qiao Jianlin, Zeng Lingyu, Li Zhenyu, Fu Chunling, Xu Kailin

Abstract excerpt

INTRODUCTION: Somatic mutations in the calreticulin (CALR) gene occur in most myeloproliferative neoplasm (MPN) patients who lack Janus kinase 2 or thrombopoietin receptor (MPL) mutations, but the molecular pathogenesis of MPN with mutated CALR is unclear, which limited the further treatment for CALR gene mutant patients. OBJECTIVES: Previous studies showed that CALR mutations not only activated serine/threonine...

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PMID: 34666331
DOI: 10.1159/000518921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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