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Article

MARIMO cells harbor a CALR mutation but are not dependent on JAK2/STAT5 signaling

24 Sept 2014

Abstract excerpt

Mutations in calreticulin ( CALR ) were recently described to be present in the majority of patients with a JAK2 -unmutated myeloproliferative neoplasm (MPN). 1 , 2 This discovery has had rapid clinical impact, and testing for CALR has been embedded in national and international diagnostic guidelines. 3 , 4 , 5 However, a human MPN-derived cell line harboring a CALR mutation has not been reported and the...

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PMID: 25249012
DOI: 10.1038/leu.2014.285

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