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Article

Structural basis for the regulation of NtcA-dependent transcription by proteins PipX and PII.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2010

Llácer José L, Espinosa Javier, Castells Miguel A, Contreras Asunción, Forchhammer Karl, Rubio Vicente

Abstract excerpt

PII, an ancient and widespread signaling protein, transduces nitrogen/carbon/energy abundance signals through interactions with target proteins. We clarify structurally how PII regulates gene expression mediated by the transcription factor NtcA, the global nitrogen regulator of cyanobacteria, shedding light on NtcA structure and function and on how NtcA is activated by 2-oxoglutarate (2OG) and coactivated by the...

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Identifiers

PMID: 20716687
DOI: 10.1073/pnas.1007015107
PMCID: PMC2932567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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