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Quantitative LC–MS/MS uncovers the regulatory role of autophagy in immune thrombocytopenia

18 Oct 2021

Abstract excerpt

BACKGROUND: Immune thrombocytopenia (ITP) is an autoimmune haemorrhagic disease whose pathogenesis is associated with bone marrow megakaryocyte maturation disorder and destruction of the haematopoietic stem cell microenvironment. METHODS: In this study, we report the qualitative and quantitative profiles of the ITP proteome. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was conducted to elucidate the...

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PMID: 34663331
DOI: 10.1186/s12935-021-02249-4

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