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Megakaryocytic dysfunction in immune thrombocytopenia is linked to autophagy

15 Mar 2019

Abstract excerpt

Immune thrombocytopenic purpura (ITP) is a multifactorial autoimmune disease characterized by both increased platelet destruction and/or reduced platelet production. Even though they are detected in ≤ 50% of ITP patients, auto-antibodies play a pivotal role in the pathogenesis of ITP. Recent experimental and clinical observations have revealed abnormal autophagy in ITP patients. Autophagy is a catabolic process...

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PMID: 30923461
DOI: 10.1186/s12935-019-0779-0

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