Article
In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential.
Cell reports - 19 Oct 2021
Lam Brandon, Kung Yu Jui, Lin John, Tseng Ssu-Hsueh, Tsai Ya Chea, He Liangmei, Castiglione Gianni, Egbert Emily, Duh Elia J, Bloch Evan M, Tobian Aaron A R, Milstone Aaron M, Roden Richard B S, Wu Tzyy-Choou, Hung Chien-Fu
Abstract excerpt
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads, variants with enhanced virulence and transmissibility have emerged. Although in vitro systems allow rapid characterization, they do not fully recapitulate the dynamic interaction of virions and neutralizing antibodies in the airway. Here, we demonstrate that the N501Y variant permits respiratory infection in unmodified mice. We utilize N501Y...
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