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Article

Plasmid fitness costs are caused by specific genetic conflicts enabling resolution by compensatory mutation.

PLoS biology - 1 Oct 2021

Hall James P J, Wright Rosanna C T, Harrison Ellie, Muddiman Katie J, Wood A Jamie, Paterson Steve, Brockhurst Michael A

Abstract excerpt

Plasmids play an important role in bacterial genome evolution by transferring genes between lineages. Fitness costs associated with plasmid carriage are expected to be a barrier to gene exchange, but the causes of plasmid fitness costs are poorly understood. Single compensatory mutations are often sufficient to completely ameliorate plasmid fitness costs, suggesting that such costs are caused by specific genetic...

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Share to Chromosomes, Bacterial
Share to Conjugation, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Genetic Fitness

Share to Plasmids

Share to Pseudomonas fluorescens

Share to Transcription, Genetic

Share to Up-Regulation

Source

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Identifiers

PMID: 34644303
DOI: 10.1371/journal.pbio.3001225
PMCID: PMC8544851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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