Article
A novel risk model incorporating 4 mitochondrial unfolded protein response-related genes to predict the prognosis, gene mutation landscape, and immunotherapy response in lung adenocarcinoma.
European journal of medical research - 21 Nov 2025
Qian Yi, Peng Jia, Jin Weiguo, Zeng Danhong, Zhou Xueqing, Li Peiyun, Zhou Jie, Zhang Baohu, Zhang Yang, Yang Shucai
Abstract excerpt
INTRODUCTION: Mitochondrial unfolded protein response (UPRmt) is implicated in lung adenocarcinoma (LUAD), and our study accordingly aims to establish a model incorporating UPRmt-related genes (MRGs) for predicting the therapeutic response and prognosis in LUAD. MATERIALS AND METHODS: The data were sourced from the cancer genome atlas (TCGA) and GSE31210 dataset and MRGs were retrieved to identify those with...
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- Humans
- Adenocarcinoma of Lung
- Prognosis
- Lung Neoplasms
- Unfolded Protein Response