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Systematical identifications of prognostic meaningful lung adenocarcinoma subtypes and the underlying mutational and expressional characters.

BMC cancer - 27 Jan 2020

Lv Zhenyang, Lei Ting

Abstract excerpt

BACKGROUND: Lung adenocarcinoma (LUAD) is one of the most common cancer types, threatening the human health around the world. However, the high heterogeneity and complexity of LUAD limit the benefits of targeted therapies. This study aimed to identify the key prognosis impacting genes and relevant subtypes for LUAD. METHODS: We recognized significant mutations and prognosis-relevant genes based on the omics data...

Topics

Adenocarcinoma of Lung
Biomarkers, Tumor
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Humans
Lung Neoplasms
Mutation
Prognosis
Unsupervised Machine Learning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31987030
DOI: 10.1186/s12885-019-6462-y
PMCID: PMC6983970

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