Article
Heme oxygenase-1 gene promotor microsatellite polymorphism is associated with angiographic restenosis after coronary stenting.
European heart journal - 1 Jan 2004
Chen Ying-Hwa, Chau Lee-Young, Lin Ming-Wei, Chen Lung-Ching, Yo Ming-Hui, Chen Jaw-Wen, Lin Shing-Jong
Abstract excerpt
AIMS: Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in heme degradation, leading to the generation of free iron, biliverdin, and carbon monoxide (CO). CO exerts potent antiproliferative and anti-inflammatory effects in the vascular walls, thereby influencing neointimal formation after vascular injury. A dinucleotide GT repeat in the promotor region of human HO-1 gene shows a length polymorphism that modulates...
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