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Article

Polygenic burden could explain high rates of affective disorders in a community with restricted founder population.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2021

Wang Xiaotong, Lin Tian, Yengo Loic, Sidorenko Julia, Wray Naomi R, Levinson Douglas F

Abstract excerpt

This study investigates if genetic factors could contribute to the high rate of mood disorders reported in a U.S. community known to have a restricted early founder population (confirmed here through runs of homozygosity analysis). Polygenic scores (PGSs) for eight common diseases, disorders, or traits, including psychiatric disorders, were calculated in 274 participants (125 mood disorder cases) who each...

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Identifiers

PMID: 34632698
DOI: 10.1002/ajmg.b.32876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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