Article
Effect of Class Switch Recombination Defect on the Phenotype of Ataxia-Telangiectasia Patients.
Immunological investigations - 1 Feb 2021
Amirifar Parisa, Mozdarani Hossein, Yazdani Reza, Kiaei Fatemeh, Moeini Shad Tannaz, Shahkarami Sepideh, Abolhassani Hassan, Delavari Samaneh, Sohani Mahsa, Rezaei Arezou, Hassanpour Gholamreza, Akrami Seyed Mohammad, Aghamohammadi Asghar
Abstract excerpt
Objectives: Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement caused by homozygous or compound heterozygous mutations in the ataxia telangiectasia mutated (ATM) gene which encodes a serine/threonine protein kinase. The aims of this study were to investigate class switch recombination (CSR) and to review the clinical and immunologic phenotypes of 3 groups...
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