Article
Circulating DNA changes are predictive of disease progression after transarterial chemoembolization.
International journal of cancer - 1 Feb 2022
Sefrioui David, Verdier Vincent, Savoye-Collet Céline, Beaussire Ludivine, Ghomadi Slim, Gangloff Alice, Goria Odile, Riachi Ghassan, Montialoux Hélène, Schwarz Lilian, Tuech Jean-Jacques, Frebourg Thierry, Michel Pierre, Sarafan-Vasseur Nasrin, Di Fiore Frédéric
Abstract excerpt
Transarterial chemoembolization (TACE) is used to treat patients with unresectable hepatocellular carcinoma (HCC). We evaluated the clinical impact of a-fetoprotein (AFP) and circulating cell-free and tumor DNA (cfDNA and ctDNA) changes around the TACE procedure. Our prospective monocentric study enrolled consecutive patients treated with TACE, with samples collected at baseline (D - 1), Day 2 (D + 2) and 1 month...
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