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N6-methyladenosine reader YTHDC2 and eraser FTO may determine hepatocellular carcinoma prognoses after transarterial chemoembolization.

Archives of toxicology - 1 May 2021

Liu Jiandong, Wang Dongyang, Zhou Jianyuan, Wang Leirong, Zhang Nasha, Zhou Liqing, Zeng Jiajia, Liu Jibing, Yang Ming

Abstract excerpt

Transarterial chemoembolization (TACE) has significantly improved overall survival (OS) of unresectable hepatocellular carcinoma (HCC) patients. Unfortunately, a portion of patients show no therapeutic responses to TACE. N6-methyladenosine (m6A) as well as its epigenetic writers, erasers, and readers play a crucial role in HCC development. However, it is still largely unclear how functional small nucleotide...

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PMID: 33713148
DOI: 10.1007/s00204-021-03021-3

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