Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression.

doi:10.1182/bloodadvances.2021004962

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Article

Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression.

Blood advances - 11 Jan 2022

Stratmann Svea, Yones Sara A, Garbulowski Mateusz, Sun Jitong, Skaftason Aron, Mayrhofer Markus, Norgren Nina, Herlin Morten Krogh, Sundström Christer, Eriksson Anna, Höglund Martin, Palle Josefine, Abrahamsson Jonas, Jahnukainen Kirsi, Munthe-Kaas Monica Cheng, Zeller Bernward, Tamm Katja Pokrovskaja, Cavelier Lucia, Komorowski Jan, Holmfeldt Linda

Abstract excerpt

Numerous studies have been performed over the last decade to exploit the complexity of genomic and transcriptomic lesions driving the initiation of acute myeloid leukemia (AML). These studies have helped improve risk classification and treatment options. Detailed molecular characterization of longitudinal AML samples is sparse, however; meanwhile, relapse and therapy resistance represent the main challenges in...

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PMID: 34619772
DOI: 10.1182/bloodadvances.2021004962
PMCID: PMC8753201

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