Article
Most genetic risk for autism resides with common variation.
Nature genetics - 1 Aug 2014
Gaugler Trent, Klei Lambertus, Sanders Stephan J, Bodea Corneliu A, Goldberg Arthur P, Lee Ann B, Mahajan Milind, Manaa Dina, Pawitan Yudi, Reichert Jennifer, Ripke Stephan, Sandin Sven, Sklar Pamela, Svantesson Oscar, Reichenberg Abraham, Hultman Christina M, Devlin Bernie, Roeder Kathryn, Buxbaum Joseph D
Abstract excerpt
A key component of genetic architecture is the allelic spectrum influencing trait variability. For autism spectrum disorder (herein termed autism), the nature of the allelic spectrum is uncertain. Individual risk-associated genes have been identified from rare variation, especially de novo mutations. From this evidence, one might conclude that rare variation dominates the allelic spectrum in autism, yet recent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.