Promoting spliceosome assembly for therapeutic intent.

Abstract excerpt

RNA splicing, the process by which precursor mRNA (pre-mRNA) is processed to mature mRNA, is catalyzed by the spliceosome. Recently, Chatrikhi et al. identified pharmacologic means to perturb splicing by enhancing the spliceosome's binding to pre-mRNA. This represents a novel chemical target and mechanism for therapeutic modulation of splicing.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mutation
• Share to RNA, Messenger
• Share to RNA Precursors