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Article

Serum Estradiol and 20 Site-Specific Cancers in Women: Mendelian Randomization Study.

The Journal of clinical endocrinology and metabolism - 18 Jan 2022

Larsson Susanna C, Kar Siddhartha, Perry John R B, Carter Paul, Vithayathil Mathew, Mason Amy M, Easton Douglas F, Burgess Stephen

Abstract excerpt

CONTEXT: The causal role of endogenous estradiol in cancers other than breast and endometrial cancer remains unclear. OBJECTIVE: This Mendelian randomization study assessed the causal associations of endogenous 17β-estradiol (E2), the most potent estrogen, with cancer risk in women. METHODS: As primary genetic instrument, we used a genetic variant in the CYP19A1 gene that is strongly associated with serum E2...

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Identifiers

PMID: 34601599
DOI: 10.1210/clinem/dgab713
PMCID: PMC8764348

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