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Article

Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype.

The Journal of cell biology - 5 Sept 2011

Rohn Jennifer L, Sims David, Liu Tao, Fedorova Marina, Schöck Frieder, Dopie Joseph, Vartiainen Maria K, Kiger Amy A, Perrimon Norbert, Baum Buzz

Abstract excerpt

Although a large number of actin-binding proteins and their regulators have been identified through classical approaches, gaps in our knowledge remain. Here, we used genome-wide RNA interference as a systematic method to define metazoan actin regulators based on visual phenotype. Using comparative screens in cultured Drosophila and human cells, we generated phenotypic profiles for annotated actin regulators...

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PMID: 21893601
DOI: 10.1083/jcb.201103168
PMCID: PMC3171124

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