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Article

A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila.

Journal of genetics and genomics = Yi chuan xue bao - 20 Aug 2012

Dui Wen, Lu Wei, Ma Jun, Jiao Renjie

Abstract excerpt

F-box proteins are components of the SCF (SkpA-Cullin 1-F-box) E3 ligase complexes, acting as the specificity-determinants in targeting substrate proteins for ubiquitination and degradation. In humans, at least 22 out of 75 F-box proteins have experimentally documented substrates, whereas in Drosophila 12 F-box proteins have been characterized with known substrates. To systematically investigate the genetic and...

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Identifiers

PMID: 22884096
DOI: 10.1016/j.jgg.2012.05.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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