Article
Polymorphisms in the serotonin transporter gene and circulating concentrations of neurotransmitters in Cavalier King Charles Spaniels with myxomatous mitral valve disease.
Journal of veterinary internal medicine - 1 Nov 2021
Reimann Maria J, Fredholm Merete, Cremer Signe E, Christiansen Liselotte B, Meurs Kathryn M, Møller Jacob E, Häggström Jens, Lykkesfeldt Jens, Olsen Lisbeth H
Abstract excerpt
BACKGROUND: The neurotransmitter serotonin (5-HT) affects valvular degeneration and dogs with myxomatous mitral valve disease (MMVD) exhibit alterations in 5-HT signaling. In Maltese dogs, 3 single nucleotide polymorphisms (SNPs) in the 5-HT transporter (SERT) gene are suggested to associate with MMVD. HYPOTHESIS/OBJECTIVES: Determine the association of SERT polymorphisms on MMVD severity and serum 5-HT...
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