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Insights into Serotonin Signaling Mechanisms Associated with Canine Degenerative Mitral Valve Disease

11 Nov 2009

Abstract excerpt

Little is known about the molecular abnormalities associated with canine degenerative mitral valve disease (DMVD). The pathology of DMVD involves the differentiation and activation of the normally quiescent mitral valvular interstitial cell (VIC) into a more active myofibroblast phenotype, which mediates many of the histological and molecular changes in affected the valve tissue. In both humans and experimental...

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PMID: 19912520
DOI: 10.1111/j.1939-1676.2009.0411.x

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