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Article

Angiotensin-converting enzyme activity in Cavalier King Charles Spaniels with an ACE gene polymorphism and myxomatous mitral valve disease.

Pharmacogenetics and genomics - 1 Feb 2018

Meurs Kathryn M, Olsen Lisbeth H, Reimann Maria J, Keene Bruce W, Atkins Clarke E, Adin Darcy, Aona Brent, Condit Julia, DeFrancesco Teresa, Reina-Doreste Yamir, Stern Joshua A, Tou Sandra, Ward Jessica, Woodruff Kathleen

Abstract excerpt

OBJECTIVES: Myxomatous mitral valve disease (MMVD) is the most common heart disease in the dog. It is particularly common in the Cavalier King Charles Spaniel (CKCS) breed and affected dogs are frequently managed with angiotensin-converting enzyme inhibitors (ACE-I). We have previously identified a canine ACE gene polymorphism associated with a decrease in angiotensin-converting enzyme (ACE) activity. The aim of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 29200408
DOI: 10.1097/FPC.0000000000000322

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ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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