Article
Multisite verification of the accuracy of a multi-gene next generation sequencing panel for detection of mutations and copy number alterations in solid tumours.
PloS one - 1 Jan 2021
Bartlett John, Amemiya Yutaka, Arts Heleen, Bayani Jane, Eng Barry, Grafodatskaya Daria, Kamel Reid Suzanne, Lariviere Mathieu, Lo Bryan, McClure Rebecca, Mittal Vinay, Sadikovic Bekim, Sadis Seth, Seth Arun, Smith Jeff, Zhang Xiao, Feilotter Harriet
Abstract excerpt
Molecular variants including single nucleotide variants (SNVs), copy number variants (CNVs) and fusions can be detected in the clinical setting using deep targeted sequencing. These assays support low limits of detection using little genomic input material. They are gaining in popularity in clinical laboratories, where sample volumes are limited, and low variant allele fractions may be present. However, data on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.