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Article

SARS-CoV-2 spike protein receptor-binding domain N-glycans facilitate viral internalization in respiratory epithelial cells.

Biochemical and biophysical research communications - 19 Nov 2021

Zheng Luping, Ma Yingxin, Chen Minghai, Wu Guoqiang, Yan Chuang, Zhang Xian-En

Abstract excerpt

N-glycosylation plays an important role in the pathogenesis of viral infections. However, the role of SARS-CoV-2 RBD N-glycosylation in viral entry remains elusive. In this study, we expressed and purified N331 and N343 N-glycosite mutants of SARS-CoV-2 RBD. We found that de-glycosylation at N331 and N343 drastically reduces the RBD binding to ACE2. More importantly, based on qualitative and quantitative virology...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34592572
DOI: 10.1016/j.bbrc.2021.09.053
PMCID: PMC8459579

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